5,7-Dichloro-1,2,3,4-tetrahydro-2-(triphenylmethyl)-6-isoquinolinecarboxylic Acid, can be sued in the preparation of novel series of compounds which has been found to be a potent LFVIP(LA)1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for treating dry eye.