4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]-benzoic acid; C 646
CAS号:
328968-36-1
分子式:
C₂₄H₁₉N₃O₆
外观:
Dark Orange Solid
熔点:
>215°C (dec.)
分子量:
445.42
储存:
Amber Vial, -20°C Freezer, Under inert atmosphere
溶解度:
DMSO (Slightly), Methanol (Slightly, Heated)
类别:
Standards; Enzyme Activators and Inhibitors;
应用:
C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO (AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.
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