Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
应用:
6-Bromo-N-hydroxy-2H-1,4-benzoxazin-3-amine is an intermediate in the synthesis of NS-2028 (N900200), potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA.
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